منابع مشابه
Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses.
Infections with parasitic helminths such as Nippostronglyus brasiliensis induce dominant type 2 responses from antigen-specific T helper cells. The potency of the Th2 bias can also drive Th2 responses to bystander antigens introduced at the same time as infection. We now report that the Th2-promoting effect of infection can be reproduced with soluble N. brasiliensis excretory-secretory proteins...
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Interleukin 7 (IL-7) protein has been reported to be important in the development of cytotoxic-T-lymphocyte (CTL) responses. However, other studies also support a partial Th2 phenotype for this cytokine. In an effort to clarify this unusual conflict, we compared IL-7 along with IL-12 (Th1 control) and IL-10 (Th2 control) for its ability to induce antigen (Ag)-specific CTL and Th1- versus Th2-ty...
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The intersection of small molecular weight drugs and antibody-based therapeutics is rarely studied in large scale. Both types of agents are currently part of the cancer armamentarium. However, very little is known about how to combine them in optimal ways. Immunotoxins are antibody-toxin gene fusion proteins engineered to target cancer cells via antibody binding to surface antigens. For fusion ...
متن کاملAdjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa.
In developing veterinary mucosal vaccines and vaccination strategies, mucosal adjuvants are one of the key players for inducing protective immune responses. Most of the mucosal adjuvants seem to exert their effect via binding to a receptor/or target cells and these properties were used to classify the mucosal adjuvants reviewed in the present paper: (1) ganglioside receptor-binding toxins (chol...
متن کاملTo scan or not to scan, to enhance or not to enhance? That is the question.
Hong Kong Med J ⎥ Volume 20 Number 5 ⎥ October 2014 ⎥ www.hkmj.org A 12-year-old boy presented to the Emergency Department (ED) with reduced level of consciousness in February 2011. Collateral history established a prehospital witnessed seizure (requiring benzodiazepine administration) preceded by auditory hallucinations. Apart from uncomplicated malaria at the age of 5 years, there was no othe...
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ژورنال
عنوان ژورنال: Allergology International
سال: 2005
ISSN: 1323-8930
DOI: 10.2332/allergolint.54.507